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Tell your doctor immediately if you develop combivir bivirkninger symptoms of worsening liver problems. Geriatric Use Clinical studies of COMBIVIR did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. DOSING: For the treatment of HIV infection the recommended oral dose for adults or children greater than 12 years of age is one tablet twice daily. In an additional teratology study in rats, dose of 3,000 mg kg day very near the oral median lethal dose in rats of 3,683 mg kg caused marked maternal toxicity and an increase in the incidence of fetal malformations. Because of both the potential for HIV-1 transmission and serious adverse reactions in nursing infants, mothers should be instructed not to breastfeed if they are receiving COMBIVIR.