Fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition. There has been long-standing concern, however, that antidepressants may have role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment. Seek immediate medical attention if any of these rare but very serious side effects occur: chest pain, slow fast irregular heartbeat, seizures, slurred speech, weakness on one side of the body, vision changes. Important Safety Information Cymbalta duloxetine HCl is approved for the treatment of tofranil haittavaikutuksia depression and generalized anxiety disorder, and for the management of diabetic peripheral neuropathic pain and fibromyalgia. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Have to find donor outside their families and less than third of them of total patients found compatible donor.